Detailed Program

Thursday, July 1, 2021

Friday, July 2, 2021

14:00 – 17:30

IC01: Introductory Course on Glial Cell Biology



Pascale Durbec (Marseille, France), Brahim Nait Oumesmar (Paris, France)


Development of glial cells

Carlos Parras (Paris, France)


Astrocytes in health and diseases 

Aude Panatier (Bordeaux, France)


Neuron-oligodendroglia interactions 

Maria Cecilia Angulo (Paris, France)


Myelin plasticity and regeneration 

Myriam Cayre (Marseille, France)


with kindly support of

NeuroSchool/ NeuroMarseille; NeurATRIS; Fondation ARC

14:00 – 20:00

IC02: Introductory Course on Glial Cell Biology


Microglia origin and function 

Alain Bessis (Paris, France)


PNS glial cells 

Piotr Topilko (Creteil, France)


Forgotten glial cells 

Ariane Sharif (Lille, France)


The role of glial cells in behavioral control 

Ethan G. Hughes (Aurora, Colorado, USA)


Insights into glioma development and cancer stem cells

Emmanuelle Huillard (Paris, France)


Open chat session with speakers

Monday, July 5, 2021

14:00 – 15:00

W01: Imaging white matter function and structure


Imaging functional interactions between axons and oligodendrocytes in vivo 

Rafael Almeida (Edinburgh, UK)


Optic nerve imaging to study axon-glial functions

Zoe J. Looser (Zurich, Switzerland)


The many ways to image myelin with the electron microscope

Wiebke Möbius (Göttingen, Germany)


Myelin on Tape –3D Ultrastructure and Targeted Electron Microscopy

Martina Schifferer (München, Germany)

W02: Physiological functions of adult microglia: implications for plasticity, learning and memory


Microglial calcium signaling is attuned to neuronal activity in the awake mouse

Anthony D. Umpierre (Rochester, USA)


Investigation of Microglial Morphodynamics during Vigilance States by Two-Photon imaging

Kassandre Combet (Lyon, France)


Studying the microglia cytoskeleton: impact of Rho GTPase ablation in microglia morphology and function

Tiago de Oliveira Almeida (Porto, Portugal)


Defective neuron-microglia crosstalk: impact on functional maturation of hippocampal synapses

Bernadette Basilico (Rome, Italy)


Microglial phagocytosis modulates adult hippocampal neurogenesis

Noelia Rodríguez-Iglesias (Leioa, Spain)


Behavioral outcomes of microglial dysfunction across the life span

Giulia Albertini (Paris, France)

W03: Thyroid hormone action in glial biology


Modeling Thyroid Hormone Action in human glia by using Induced Pluripotent Stem Cell

Nilhan Gunhanlar (Rotterdam, Netherlands)


The role of transthyretin in oligodendrocyte development and central nervous system myelination in rodents.

Maurice Pagnin (Bundoora, Melbourne, Australia)


Hypothalamic tanycyte-neuron interaction evokes global changes in thyroid hormone economy

Richárd Sinkó (Budapest, Hungary)


A multidisciplinary approach exploring the role of the thyroid hormone transporter MCT8 in oligodendrocyte maturation and myelination.

Víctor Valcárcel-Hernánde (Madrid, Spain)


Developmental thyroid hormone action determines the later-life neuro/glia output in the murine subventricular zone

Pieter Vancamp (Paris, France)

15:00 – 16:30

L01: Opening & Plenary Lecture of Magdalena Götz

Chair: Leda Dimou (Ulm, Germany)



Helmut Kettenmann (Berlin, Germany), Pascale Durbec (Marseille, France)


Astrocyte heterogeneity: from stem cells to repair

Magdalena Götz (Neuherberg-Munich, Germany)

16:30 – 18:00

Networking and Poster Session A

18:00 – 19:00

S03: Microglial immunometabolism: relevance in normal and disease states


Role of TREM2 and APOE in microglial lipid metabolism

Bettina Van Lengerich (South San Francisco, USA)


Role of lipid nutrients on microglial function in the developing brain

Agnes Nadjar (Bordeaux, France)


Targeting Mitochondrial Metabolism in Neuroinflammation with Neural Stem Cells and their Cargo Vesicles

Stefano Pluchino (Cambridge, UK)


Hypothalamic microglia-neuron interaction in obesity and type 2 diabetes.

Chun-Xia Yi (Amsterdam, Netherlands)

S13: Advances in cellular reprogramming: where biology meets physics


Mathematical models of cellular identity converge with models of neural networks and provide framework for cellular identity

Ton Coolen (London, UK)


An integrated multi-omics-analysis provides mechanistic insight into the process of iPSC-to-neuron reprogramming.

Mark Kotter (Cambridge, UK)


Programming human pluripotent stem cells into microglia – a new model to study CNS disease

Anna Speicher (Muenster, Germany)


Next generation cell therapies for the brain

Marius Wernig (Stanford, USA)


with kindly support of

S17: Mechanics of glial cells in development and disease


Mechanosensing Controls Myelin Sheath Elongation in the CNS

Marie Bechler (Syracuse, USA)


Brain tissue mechanics and mechanobiology of glial cells

Katarzyna Pogoda (Krakow, Poland)


Machine learning in direct glia-to-neuron reprogramming to a neuronal fate: Learning from cell mechanics for fate prediction

Marcelo Salierno (London, UK)


How do oligodendrocytes add new membrane to build the myelin sheath?

Bradley Zuchero (Stanford, USA)

Tuesday, July 6, 2021

13:30 – 14:30

S07: Molecular Mechanisms Controlling Neural Stem Cell Dynamics During Aging


Mathematical modeling of age-dependence of adult neurogenesis

Anna Marciniak-Czochra (Heidelberg, Germany)


Glucocorticoid circadian oscillations control the architecture of the adult hippocampal neurogenic niche in the aging brain.

Carlos Fitzsimons (Amsterdam, Netherlands)


Progressive changes in hippocampal stem cell properties ensure lifelong neurogenesis

Lachlan Harris (London, UK)


Origin and Aging of Adult Hippocampal Neural Stem Sells

Juanma Encinas (Leioa, Spain)

S09: Glial cells in the limelight of metabolic signaling: experiments in mouse and fly


Astroglial insights to the paradox of brain aerobic glycolysis

L.Felipe Barros (Valdivia, Chile)


Glia-neuron metabolic interactions beyond lactate

Stefanie Schirmeier (Münster, Germany)


Glial Lactate fuels neuronal activity, a fly view

Jimena Sierralta (Santiago, Chile)


Astrocytes store and release lactate on demand: Evidence derived from awake behaving mice.

Bruno Weber (Zurich, Switzerland)

S14: Perisynaptic astroglial processes: activity-dependent regulation and function 


Investigating astrocytic Ca2+ signals with STED and lattice light sheet microscopy

Misa Arizono (Bordeaux Cedex, France)


Activity-dependent regulation of the molecular repertoire in perisynaptic astroglial processes

Nathalie Rouach (Paris, France)


Activity-driven plasticity of perisynaptic astroglial environment

Dmitri Rusakov (London, UK)


Proteomic and functional analyses of perisynaptic astroglial process dynamics

Mark Verheijen (Amsterdam, Netherlands)

14:30 – 15:30

L02: Plenary Lecture of Sonia Garel

Chair: Pascale Durbec (Marseille, France)


Neuroimmune interactions in early brain wiring

Sonia Garel (Paris, FR)


with kindly support of International Society for Developmental Neuroscience (ISDN)

15:30 – 17:00

Networking and Poster Session B

15:30 – 16:15

Workshop by Miltenyi Biotec  BV & Co. KG: Whole brain imaging at subcellular resolution with the fully automated UltraMicroscope Blaze™


Speaker: Dr. Elisa Nent, Dr. Hussein Hamzeh


Light sheet microscopy in combination with tissue clearing enables 3D visualization of intact rodent brains and even an entire mouse body at cellular and subcellular level. In this workshop, we will introduce you to large-scale 3D fluorescence imaging with the brand-new UltraMicroscope Blaze – the first fully automated light sheet microscope for large or multiple samples. With cutting-edge light sheet optics, the microscope operates as a virtual microtome which performs section-free high-resolution 3D imaging. You will learn how light sheet imaging enables you to obtain an unbiased view at large samples such as cleared brains or brain organoids, from neural networks down to subcellular details, at an accelerated pace.

17:00 – 18:00

S01: Microglia shape white matter health


Microglia refine myelin formation by phagocytosis during development

Bruce Appel (Aurora, USA)


Microglial interaction with nodes of Ranvier in physiological and pathological contexts

Anne Desmazieres (Paris, France)


Microglia regulate the integrity of myelin in the central nervous system

Veronique Miron (Edinburgh, UK)


Single cell mass cytometry of human white matter microglia in health and disease

Josef Priller (Berlin, Germany)

S02: Transcriptional control of reactive astrocyte responses across neurological diseases


Developmental insight into diverse reactive astrocyte responses after injury and degeneration

Benjamin Deneen (Houston TX, USA)


Role of reactive astrogliosis in Alzheimer’s disease and stroke

Gabor C. Petzold (Bonn, Germany)


Transcriptional regulation of astrocyte plasticity in brain homeostasis, injury and tumor-associated astrocytes

Florian Siebzehnrubl (Cardiff, UK)


Systematic analysis of astrocytes after spinal cord injury unveils heterogeneity and important regulatory genes in astrogliosis

Jiaqian Wu (Houston TX, USA)

S24: Glia-axonal communication in nervous system injury and disease


Do injured axons signal to Schwann cells prior to axon degeneration?

Peter Arthur-Farraj (Cambridge, UK)


Probing cellular and molecular mechanisms of peripheral nerve regeneration using zebrafish

Michael Granato (Philadelphia, USA)


Exploring transcriptional responses that govern glial immune responses to injury in Drosophila.

Mary Logan (Portland, USA)


Neuregulin-1 signaling in repair responses of peripheral nerve diseases

Ruth Stassart (Leipzig, Germany)

18:00 – 19:00

L03: Plenary Lecture of Jonah Chan

Chair: Dwight Bergles (Baltimore, USA)


Oligodendrocytes and myelin: sculpting circuits in development and in adulthood

Jonah Chan (San Francisco, US)

Wednesday, July 7, 2021

13:30 – 14:30

S16: Microglia; from development to ageing


The role of glia cells in Alzheimer’s Disease

Bart de Strooper (London, UK)


Human microglia in the healthy and diseased CNS

Bart J. L. Eggen (Groningen, Netherlands)


A human(ized) system to study microglial biology ex vivo

Deborah Kronenberg-Versteeg (Tuebingen, Germany)


Microglia shape the development of neuronal network

Balazs V. Varga (Cambridge, UK)

S20: Metabolic control of glial identity phenotype and function        


How lipid metabolism regulates adult neural stem cells

Marlen Knobloch (Lausanne, Switzerland)


Mitochondrial metabolism governs myeloid cell function in the chronically inflamed central nervous system.

Luca Peruzzotti-Jametti (Cambridge, UK)


Title tba.

Marco Prinz (Freiburg, Germany)


Control of astrocyte heterogeneity in CNS inflammation

Francisco Javier Quintana (Boston MA, USA)

S27: Emerging pathways and therapies to enhance Repair Schwann cells functions


Different cell types cooperate with repair Schwann cells to promote nerve regeneration inside a hollow conduit used to repair a nerve gap.

Giovanna Gambarotta (Torino, Italy)


The well documented failures of nerve repair seen during aging and chronic denervation involve reduced Schwann cell c-Jun, and are rescued by restoring c-Jun levels.

Kristjan Jessen (London, UK)


YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

Yannick Poitelon (ALBANY, USA)


Mechanisms controlling pns myelin maintenance

Carla Taveggia (Milan, Italy)

14:30 – 15:30

L04: Plenary Lecture of David Lyons

Chair: Robin Franklin (Cambridge, UK)


Studying myelinated axon biology in vivo using zebrafish

David Lyons (Edinburgh, UK)

15:30 – 17:00

Networking and Poster Session C

17:00 – 18:00

S04: Glial regulation and remodeling of the extracellular matrix across the lifespan


Microglia, memories, and the extracellular matrix

Anna Victoria Molofsky (San Francisco, USA)


Niche stiffness underlies the ageing of oligodendrocyte progenitor cells

Kevin Chalut (Cambridge, UK)


Super-resolution imaging of the dynamics of glial cells and the extracellular space

Valentin Nägerl (Bordeaux, France)


Ankyrin-dependent regulation of glia-derived extracellular matrix

Matthew Rasband (Houston, USA)

S05: Mechanisms and effects of endocannabinoid signaling in glial cells


Functional consequences of endocannabinoid signaling at Tripartite Synapses

Alfonso Araque (Minneapolis, USA)


Cortical cannabinoid receptor type-2 signalling in microglia-to-neuron communication

Silvia Marinelli (Roma, Italy)


Mitochondrial CB1 receptors: beyond the metabolic and synaptic dychotomy of astroglial functions

Giovanni Marsicano (Bordeaux, France)


Endocannabinoid-mediated control of astrocytes in multiple sclerosis

Susana Mato (Leioa, Spain)

S06: Myelin Dynamics in Neurological Function and Dysfunction


Oligodendrogenesis and Myelin Formation in Memory Consolidation

Patrick Steadman (Toronto, Canada)


Glia-mediated Mechanisms of Chemotherapy-related Cognitive Impairment

Erin Gibson (Palo Alto, USA)


Social experience-dependent myelin plasticity: an epigenetic view

Jia Liu (New York, USA)


Myelin influences synaptic plasticity in the adult mouse cortex

Kaylene Young (Tasmania, Australia)

18:00 – 19:00

L05: Plenary Lecture of Nicola Allen

Chair: Brian MacVicar (Vancouver, BC, Canada)


Astrocyte regulation of neuronal synapses

Nicola  Allen (La Jolla, US)

Thursday, July 8, 2021

13:30 – 14:30

S12: Metabolic aspects in myelinating glia: implications for health and disease


The role of autophagy in the development and maintenance of myelin in oligodendrocytes

Domna Karagogeos (Heraklion, Greece)


Schwann cells autophagy: fast and immediate clearance of aggresomes for counteracting peripheral neurodegeneration.

Sara Marinelli (Rome, Italy)


Myelin lipids are energy reserves of the nervous system

Klaus Armin Nave (Göttingen, Germany)


Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance

Teresa Wood (Newark NJ, USA)

S25: Satellite glial cells – unique glia of the peripheral nervous system


Recent insight into the SGC transcriptional injury response

Sara Jager (London, UK)


The pharmacology of satellite glial cells

Stefania Ceruti (Milan, Italy)


Neuron-satellite glia interactions and pain

Menachem Hanani (Jerusalem, Israel)


Diversity of satellite glia in sympathetic and sensory ganglia

Aurelia Mapps (Baltimore, USA)

S26: Innate Immunity and Microglia


Microglial opsonins, chaperones and alarmins

Guy Brown (Cambridge, UK)


Immune memory and microglial phagocytosis

Jonas Neher (Tuebingen, Germany)


Intact sialylation prevents complement C3-mediated loss of neurons in the brain of mice

Harald Neumann (Bonn, Germany)


Phagocytosis of apoptotic cells: the light at the end of the tunnel for microglia

Amanda Sierra (Leioa, Spain)

14:30 – 15:30

S15: Glial modulation of circuit assembly and behavior: insights from different model organisms


C. elegans glia drive brain assembly through specialized morphogenesis and crosstalk with neurons

Georgia Rapti (Heidelberg, Germany)


Glia-MB acetylcholine-mediated synaptic connections underlie Drosophila long term memory

Margaret Ho (Shanghai, China)


Title tba.

Misha Ahrens (VA, USA)


Astroglial control of C. elegans behavior

Shai Shaham (New York, USA)

S29: Extracellular vesicles shape glia-neuron interplay in health and disease of the nervous system


Extracellular vesicles secreted by ethanol-treated astrocytes participates in glial-neuron communication spreading the neuroinflammation via TLR4

Consuelo Guerri (Valencia, Spain)


Oligodendrocyte-derived exosomes in axon-glia interaction and glial support

Eva Maria Krämer-Albers (Mainz, Germany)


Extracellular vesicles act as disease propagator in amyotrophic lateral sclerosis and frontotemporal dementia

Davide Trotti (Philadelphia, USA)


Dysfunctional astroglial exosome signaling to (motor) neuron axon in ALS models

Yongjie Yang (Boston, USA)

S30: Exploring the regenerative properties of Müller glia for retinal repair


Müller glial cell reprogramming and retina regeneration in zebrafish

Daniel Goldman (Ann Arbor, USA)


Müller cells respond to focal laser injury with either retinal regeneration or reactive gliosis

Volker Enzmann (Bern, Switzerland)


Interplay between Müller glia and microglia during retinal regeneration

Muriel Perron (Orsay, France)


Insights into the inhibitory controls that prevent murine Müller glia regeneration in the retina

Carol Schuurmans (Toronto Ontario, Canada)

15:30 – 17:00

Networking and Poster Session D

17:00 – 18:00

S08: Blood brain barrier, neuronal activity and glia    


Neurovascular Interactions: Mechanisms, Imaging, Therapeutics

Katerina Akassoglou (San Francisco, USA)


Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance

Stefan Liebner (Frankfurt/Main, Germany)


Blood-brain barrier pericytes reactivity and MRI in epilepsy: from pathophysiology to target strategies

Nicola Marchi (Montpellier Cedex, France)


The impact of enhanced neuronal activity on neuron-OPC interactions in the hippocampus

Friederike Pfeiffer (Storrs, Germany)

S10: Where do Glia Come From? Evolution and Diversification of CNS Glia         


Interlaminar astrocytes evolution in mammals

Carmen Falcone (Sacramento, USA)


Glial and microglial functions: connecting the nervous and the immune system in evolution

Angela Giangrande (Strasbourg, France)


Evolution of the oligodendrocyte cell type and adaptive myelination phenotype

Jacob H. Hines (Winona, USA)


Human-specific gene expression patterns in oligodendrocytes

Genevieve Konopka (Dallas, USA)

S28: Modulating reactive astrogliosis: a therapeutic strategy


Parsing out the role of resting and reactive astrocytes in disease

Lynette Foo (Basel, Switzerland)


Astrocyte microglia cross-talk in prion diseases and beyond

Susanne Krasemann (Hamburg, Germany)


Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell autonomous neuronal degeneration

Giovanna Mallucci (Cambridge, UK)


Effects of modulating astrocyte reactivity via loss-of-function manipulations

Michael V. Sofroniew (Los Angeles, USA)


supported by F. Hoffmann-La Roche Ltd.

18:00 – 19:00

L06: Plenary Lecture of Jonas Frisén

Chair: Benedikt Berninger (London, UK)


Scar formation in the injured spinal cord – mechanisms and opportunities

Jonas Frisén (Stockholm, Sweden)

Friday, July 9, 2021

13:30 – 14:30

S11: Neuron to Microglia communication: neuromodulators and purines get on the front scene   


Microglia-neuron interactions through somatic purinergic junctions

Adam Denes (Budapest, Hungary)


Microglial dynamics impact synaptic surveillance and plasticity

Anna Majewska (Rochester, USA)


Serotonergic control of microglia during development controls innate behaviors and response to systemic inflammation in adulthood

Anne Roumier (Paris, France)


Neuronal regulation of microglial TNF release controls synaptic strength and circuit function

David Stellwagen (Montreal, Canada)

S19: Studying glia with single cell resolution (Special Trainee Symposium)


Nightlife of the astrocytes: Insights into astrocytic Ca2+ signaling in mice during natural sleep

Laura Bojarskaite (Oslo, Norway)


On the discovery of population-specific state transitions from multi-sample multi-condition scRNA-seq data

Helena Lucia Crowell (Zurich, Switzerland)


Neuroinflammatory astrocyte subtypes in the mouse brain

Philip Hasel (New York, USA)


Oligodendrocyte heterogeneity during myelin regeneration

Sarah Neely (Edinburgh, UK)


Single nuclei transcriptomic profiling of human astrocytes and oligodendrocytes in Alzheimer’s disease

Jessica Sadick (New York, USA)

S23: Mitochondrial regulation of astrocyte function in physiological and pathological conditions 


Mitochondrial structure and calcium dynamics in astrocytes

Amit Agarwal (Heidelberg, Germany)


Mitochondrial network dynamics in reactive astrocytes

Matteo Bergami (Cologne, Germany)


Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation: implication for 22q11 deletion syndrome

Paola Bezzi (Lausanne, Switzerland)


Astrocytic Mitochondrial Dysfunctions During Dementia

Kevin Richetin (Prilly-Lausanne, Switzerland)

14:30 – 15:30

S18: Targeting glial cell activation for treatment of neurodegenerative disease


Neuroimmune cell atlas for the human brain reveals gene networks activated in neurological disorders

Seth A. Ament (Baltimore, USA)


Targeting a signal of glial activation: clinical evaluation of Semaphorin 4D blocking antibody pepinemab

Elizabeth Evans (Rochester, USA)


White matter microglia activation and cognitive impariment

Shawn Whitehead (London, Canada)


Imaging glucose metabolism

Eduardo Zimmer (Porto Alegre, Brazil)

S21: Sex differences in glia                


A cell-autonomous pathway that controls sexually dimorphic gene expression in glia

Maxwell Heiman (Boston MA, USA)


Microglia sexual differentiation

Adriana Maggi (Milan, Italy)


Microglia developmentally regulate astrocyte and neuron number creating enduring sex-specific behavioral changes

Margaret McCarthy (Baltimore MD, USA)


Sexual dimorphism of microglia molecular states

Susanne Wolf (Berlin, Germany)

S22: Understanding the role of glia in neurodevelopmental disorders using pluripotent stem cell-derived human glia


Modeling neurodevelopmental disorders using induced astrocytes

Ella Quist (Lund, Sweden)


Suppresion of PLP1 for Pelizaeus Merzbacher Disease

Paul Tesar (Cleveland, USA)


Modeling Neurodevelopmental Disorder Using Human iPSC-Based Microglial Mouse Chimeras

Peng Jiang (Piscataway, USA)


Human Astrocytes in Neurological Diseases

Su-Chun Zhang (Singapore, Singapore)


with kindly support of International Society for Developmental Neuroscience (ISDN)

15:30 – 17:00

Networking and Poster Session E

17:00 – 18:30

L07: Plenary Lecture of Alison Lloyd & Closing

Chair: Claire Jacob (Fribourg, Switzerland)


Peripheral nerve homeostasis, damage and repair

Alison Lloyd (London, UK)


Closing & Invitation to GLIA 2023

Helmut Kettenmann (Berlin, Germany), Pascale Durbec (Marseille, France)

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